STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF RETINOID CANCER INHIBITION

被引：23

作者：

JAEGER, EP

JURS, PC

STOUCH, TR

机构：

[1] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,POB 4000,PRINCETON,NJ 08543

[2] STERLING WINTHROP PHARMACEUT RES DIV,RENSSELAER,NY 12144

[3] PENN STATE UNIV,DAVE LAB CHEM 152,UNIV PK,PA 16802

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 28卷 / 04期

关键词：

RETINOIDS; CANCER; CANCER INHIBITION; MULTIVARIATE ANALYSIS; PATTERN RECOGNITION; SAR; STRUCTURE ACTIVITY RELATIONSHIPS;

D O I：

10.1016/0223-5234(93)90145-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A structure-activity relationship (SAR) is described between 152 retinoid structures and their biological activity in an in vitro test that correlates with cancer prophylaxis. Using 18 molecular features, multivariate analysis was used to build and evaluate an SAR that correctly classified 94% of the 152 structures. Blind studies correctly predicted the biological activities of 17 of 19 new compounds (89%).

引用

页码：275 / 290

页数：16

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