SEVERAL LIVER-SPECIFIC DNASE HYPERSENSITIVE SITES ARE PRESENT IN THE INTERGENIC REGION SEPARATING HUMAN PLASMINOGEN AND APOPROTEIN(A) GENES

被引：17

作者：

MAGNAGHI, P ^{[1
]}

MIHALICH, A ^{[1
]}

TARAMELLI, R ^{[1
]}

机构：

[1] IST SCI SAN RAFFAELE,MILAN,ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 205卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.2754

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The genes coding for plasminogen and apoprotein(a) are clustered, together with two related genes, on the telomeric region of chromosome 6 at band 6q26-27. Moreover, the two genes are 40 Kb apart and transcriptionally pointing to opposite directions. Plasminogen and apoprotein(a) share a high degree of homology in the promoter and 5' flanking regions and their expression is mainly confined to liver. To assess whether common controlling elements mediate the tissue specific expression of these two genes, the region between them was investigated for DNase hypersensitive sites in hepatic cell nuclei. (C) 1994 Academic Press, Inc.

引用

页码：930 / 935

页数：6

共 13 条

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