BRAIN-LESIONS AND COGNITIVE FUNCTION IN LATE-LIFE PSYCHOSIS

被引：95

作者：

MILLER, BL

LESSER, IM

BOONE, KB

HILL, E

MEHRINGER, CM

WONG, K

机构：

[1] UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,DEPT PSYCHIAT,TORRANCE,CA 90509

[2] UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,DEPT RADIOL,TORRANCE,CA 90509

来源：

BRITISH JOURNAL OF PSYCHIATRY | 1991年 / 158卷

关键词：

D O I：

10.1192/bjp.158.1.76

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Twenty-four patients who developed their first psychotic episode after the age of 45 were studied with MRI and comprehensive neuropsychological testing and compared with 72 healthy elderly subjects. The patients demonstrated more clinical abnormalities on MRI, were more likely to have large white-matter lesions or metabolic illness, and did more poorly on many neuropsychological tests, particularly those testing frontal-lobe and memory abilities. We conclude that structural brain injury is commonly associated with the late onset of psychosis. Neuroimaging investigations are a valuable component in the evaluation of this patient group.

引用

页码：76 / 82

页数：7