A SHORT CHEMOENZYMATIC ROUTE TO GLYCOSPHINGOLIPIDS USING SOLUBLE GLYCOSYL TRANSFERASES

被引：14

作者：

GUILBERT, B ^{[1
]}

FLITSCH, SL ^{[1
]}

机构：

[1] DYSON PERRINS LAB,OXFORD OX1 3QY,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 09期

关键词：

D O I：

10.1039/p19940001181

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two commercially available soluble glycosyl transferases, a beta-1,4-galactosyl transferase from bovine milk and an alpha-2,6-sialyl transferase from rat liver, were used for the synthesis of several glycosphingolipids. The synthetic strategy involves the chemical synthesis of 2-azido- and 2-amino-sphingosine glycosides (5, 6, 10 and 11) and further glycosylation of their sugar headgroups to complex glycolipids. The azido- or amino-sphingosine lipid sidechain can then be further elaborated by reduction and/or acylation.

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页码：1181 / 1186

页数：6

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