POTENT INHIBITORS OF TYROSINASE ACTIVITY AND MELANIN BIOSYNTHESIS FROM RHEUM-OFFICINALE

被引：42

作者：

IIDA, K

SHIMOMURA, K

SUDO, S

KADOTA, S

NAMBA, T

机构：

[1] TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU TRADIT SINO JAPANESE MED,SUGITANI,TOYAMA 93001,JAPAN

[2] MIKIMOTO PHARMACEUT CO LTD,ISE 516,JAPAN

来源：

PLANTA MEDICA | 1995年 / 61卷 / 05期

关键词：

RHEUM OFFICINALE BAILLON; POLYGONACEAE; TYROSINASE INHIBITOR; MELANIN BIOSYNTHESIS INHIBITOR; STILBENES; B-16 MELANOMA CELLS; HYPERPIGMENTATION;

D O I：

10.1055/s-2006-958129

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Thirty-three crude drug extracts were screened for their tyrosinase inhibitory activity. Among them, the acetone extract of the rhizomes of Rheum officinale Baillon showed the strongest inhibitory activity. Tyrosinase inhibitory activity-guided fractionation and chemical analysis led to the isolation of two potent compounds, 3,4',5-trihydroxystilbene-4'-O-beta-D-(2 ''-O-galloyl)glucopyranoside (1) and 3,4',5-trihydroxystilbene-4'-O-beta-D-(6 ''-O-galloyl)glucopyranoside (2). These compounds showed a competitive inhibition against tyrosinase and also inhibited the melanin biosynthesis.

引用

页码：425 / 428

页数：4

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