SEQUENCE AND STRUCTURE CORRELATION OF HUMAN RIBOSOMAL TRANSCRIBED SPACERS

被引：93

作者：

GONZALEZ, IL ^{[1
]}

CHAMBERS, C ^{[1
]}

GORSKI, JL ^{[1
]}

STAMBOLIAN, D ^{[1
]}

SCHMICKEL, RD ^{[1
]}

SYLVESTER, JE ^{[1
]}

机构：

[1] UNIV PENN,SCH MED,DEPT HUMAN GENET,PHILADELPHIA,PA 19104

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1990年 / 212卷 / 01期

关键词：

D O I：

10.1016/0022-2836(90)90302-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the sequences of the transcribed spacers of human rRNA that now allow us to piece together the entire primary transcript sequence of approximately 13.3 × 103 basepairs. Comparison of transcribed spacer sequences with those of variable regions of rRNA and with those of the non-transcribed spacers supports the hypothesis that the variable regions are descended from transcribed spacers. Nucleotide sequence-derived secondary structures for the 5′ external transcribed spacer and for internal transcribed spacers 1 and 2 match both the sizes and shapes of the structures that were visualized 15 years ago on electron micrographs. Parts of these structures are conserved in mammals and may be related to transcript processing. © 1990.

引用

页码：27 / 35

页数：9

共 35 条

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