INVOLVEMENT OF SEX-HORMONE IN BODY-WEIGHT GAIN BY SELECTIVE D2-RECEPTOR ANTAGONIST SULPIRIDE

被引：13

作者：

SHIMIZU, H

SHIMOMURA, Y

UEHARA, Y

KOBAYASHI, I

KOBAYASHI, S

机构：

[1] First Department of Internal Medicine, Section of Endocrinology, Central Laboratory for Clinical Investigation, Gunma University School of Medicine, Maebashi

来源：

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY | 1990年 / 96卷 / 01期

关键词：

Estrogen; Feeding behavior; Rat; Sulpiride;

D O I：

10.1055/s-0029-1210984

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of estrogen supplement on selective D2receptor antagonist sulpiride induced weight gain was examined in ovariectomized (ovx.) rats. Sulpiride injection (10 mg/kg, s.c.) showed a significant increase of body weight and food consumption only in female rats. Bilateral ovariectomy completely abolished the weight gain and hyperphagia by sulpiride. Subcutaneous injection of estradiol benzoate (E2: 5 μg/day, s. c.) for 14 days restored the effects of sulpiride on weight gain in ovx. rats and sulpiride injection with E2supplement significantly increased the efficiency of food utilization. The present study suggested that estrogen should be involved in the induction of overweight and hyperphagia by sulpiride. © 1990, J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart, New York. All rights reserved.

引用

页码：25 / 29

页数：5

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