MURINE M290 INTEGRIN EXPRESSION MODULATED BY MAST-CELL ACTIVATION

被引：58

作者：

SMITH, TJ

DUCHARME, LA

SHAW, SK

PARKER, CM

BRENNER, MB

KILSHAW, PJ

WEIS, JH

机构：

[1] HARVARD UNIV, BRIGHAM & WOMENS HOSP,SCH MED, DEPT RHEUMATOL IMMUNOL,LYMPHOCYTE BIOL SECT, BOSTON, MA 02115 USA

[2] HARVARD UNIV, BRIGHAM & WOMENS HOSP,SCH MED, DEPT RHEUMATOL IMMUNOL,DIV MED SCI, BOSTON, MA 02115 USA

[3] AFRC, BABRAHAM INST, DEPT IMMUNOL, CAMBRIDGE CB2 4AT, ENGLAND

来源：

IMMUNITY | 1994年 / 1卷 / 05期

关键词：

D O I：

10.1016/1074-7613(94)90070-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intraepithelial T lymphocytes possess a (TGF beta)-inducible integrin complex that consists of the beta 7 integrin chain in association with a novel alpha chain, murine alpha M290. Using antibodies directed against the murine alpha M290 chain, IL-3-dependent murine bone marrow-derived mast cells demonstrated positive staining after induction with TGF beta. Sequence information from the human intraepithelial T lymphocyte-alpha E gene sequence was used to clone the murine homolog from a TGF beta-induced T cell library. The murine alpha E homolog gene encodes a protein recognized by antibodies to alpha M290. Expression of this gene by bone marrow-derived mast cells was found to be induced by TGF beta or IgE-mediated cross-linking of Fc epsilon R1. Furthermore, exposure of murine TK-1 cells to supernatants from activated mast cells induces the expression of the alpha M290 gene, indicating that a mast cell mediator(s) can act in a paracrine manner to induce expression of this integrin complex by other cells.

引用

页码：393 / 403

页数：11

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