SYNTHESES OF 3-ACYL-4-HYDROXY-2(1H)QUINOLONES

被引：49

作者：

KAPPE, T

AIGNER, R

HOHENGASSNER, P

STADLBAUER, W

机构：

[1] Institute of Organic Chemistry, Karl-Franzens-University, Graz

来源：

JOURNAL FUR PRAKTISCHE CHEMIE-CHEMIKER-ZEITUNG | 1994年 / 336卷 / 07期

关键词：

D O I：

10.1002/prac.19943360707

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

3-Acyl-4-hydroxy-2(1H)-quinolones 5 are obtained by hydrolytic ring opening and subsequent decarboxylation from the corresponding pyrano[3,2-c]quinolin-2,5(6H)-diones 4, which in turn are easily obtained from 1:2 condensation of anilines 1 with diethyl malonate 2a or 1:1 condensation of diethyl alkyl- or arylmalonates 2b-e with 4-hydroxy-2(1H)-quinolones 3. Nitropyranoquinolinediones 6 furnish after ringopening 3-nitroacetyl-4-hydroxy-2(1H)quinolones 8. Pyranoquinolines 7 and 9 with acetyl- or aminosubstituents are hydrolyzed during basic ringopening to yield 5.

引用

页码：596 / 601

页数：6

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