1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) AND 1-METHYL-4-PHENYLPYRIDINE (MPP+) CAUSE RAPID ATP DEPLETION IN ISOLATED HEPATOCYTES

被引：162

作者：

DIMONTE, D

JEWELL, SA

EKSTROM, G

SANDY, MS

SMITH, MT

机构：

来源：

关键词：

D O I：

10.1016/0006-291X(86)91211-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：310 / 315

页数：6

共 15 条

[1] CATAGNOLI N, 1985, LIFE SCI, V36, P225
[2] METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE
CHIBA, K
TREVOR, A
CASTAGNOLI, N
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) : 574 - 578
[3] DIMONTE D, 1986, BIOCH BIOPHYS RES CO
[4] OXIDATION OF GLUTATHIONE DURING HYDROPEROXIDE METABOLISM - A STUDY USING ISOLATED HEPATOCYTES AND THE GLUTATHIONE-REDUCTASE INHIBITOR 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA
EKLOW, L
MOLDEUS, P
ORRENIUS, S
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1984, 138 (03): : 459 - 463
[5] Hackenbrock CR., 1978, METHOD ENZYMOL, P36, DOI [DOI 10.1016/0076-6879(78)57006-7, 10.1016/0076-6879(78)57006-7]
[6] HEIKKILA RE, 1984, NATURE, V311, P467, DOI 10.1038/311467a0
[7] 1-METHYL-4-PHENYLPYRIDINE (MPP+) INDUCES OXIDATIVE STRESS IN THE RODENT
JOHANNESSEN, JN
ADAMS, JD
SCHULLER, HM
BACON, JP
MARKEY, SP
[J]. LIFE SCIENCES, 1986, 38 (08) : 743 - 749
[8] LAMPRECHT W, 1974, METHODEN ENZYMATISCH, P2151
[9] Moldeus P, 1978, Methods Enzymol, V52, P60
[10] INHIBITION OF NADH-LINKED OXIDATION IN BRAIN MITOCHONDRIA BY 1-METHYL-4-PHENYL-PYRIDINE, A METABOLITE OF THE NEUROTOXIN, 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE
NICKLAS, WJ
VYAS, I
HEIKKILA, RE
[J]. LIFE SCIENCES, 1985, 36 (26) : 2503 - 2508