RAPID AGONIST-INDUCED BETA-ADRENERGIC-RECEPTOR KINASE TRANSLOCATION IN C6 GLIOMA-CELLS

被引：14

作者：

GARCIAHIGUERA, I ^{[1
]}

MAYOR, F ^{[1
]}

机构：

[1] UNIV AUTONOMA MADRID, CSIC, Dept Biol Mol, Ctr Biol Mol Severo Ochoa CBM, E-28049 MADRID, SPAIN

来源：

FEBS LETTERS | 1992年 / 302卷 / 01期

关键词：

BETA-ADRENERGIC RECEPTOR KINASE; DESENSITIZATION; TRANSLOCATION;

D O I：

10.1016/0014-5793(92)80285-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exposure of C6 glioma cells to 1-mu-M isoproterenol leads to fast desensitization of the beta-adrenergic receptor/adenylyl cyclase system and transient receptor sequestration. It also triggers a very rapid and transient translocation to the plasma membrane of beta-adrenergic receptor kinase (beta-ARK), a specific cytoplasmic kinase that phosphorylates only the agonist-occupied form of several G protein-coupled receptors. beta-ARK-mediated receptor phosphorylation appears to be a suitable mechanism for the rapid regulation of adrenergic receptor function in the nervous tissue.

引用

页码：61 / 64

页数：4

共 19 条

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