RAPID AGONIST-INDUCED BETA-ADRENERGIC-RECEPTOR KINASE TRANSLOCATION IN C6 GLIOMA-CELLS

被引:14
作者
GARCIAHIGUERA, I [1 ]
MAYOR, F [1 ]
机构
[1] UNIV AUTONOMA MADRID, CSIC, Dept Biol Mol, Ctr Biol Mol Severo Ochoa CBM, E-28049 MADRID, SPAIN
关键词
BETA-ADRENERGIC RECEPTOR KINASE; DESENSITIZATION; TRANSLOCATION;
D O I
10.1016/0014-5793(92)80285-O
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Exposure of C6 glioma cells to 1-mu-M isoproterenol leads to fast desensitization of the beta-adrenergic receptor/adenylyl cyclase system and transient receptor sequestration. It also triggers a very rapid and transient translocation to the plasma membrane of beta-adrenergic receptor kinase (beta-ARK), a specific cytoplasmic kinase that phosphorylates only the agonist-occupied form of several G protein-coupled receptors. beta-ARK-mediated receptor phosphorylation appears to be a suitable mechanism for the rapid regulation of adrenergic receptor function in the nervous tissue.
引用
收藏
页码:61 / 64
页数:4
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