BETA-CARBOLINES AND TETRAHYDROISOQUINOLINES - DETECTION AND FUNCTION IN MAMMALS

被引：69

作者：

ROMMELSPACHER, H

MAY, T

SUSILO, R

机构：

来源：

PLANTA MEDICA | 1991年 / 57卷

关键词：

BETA-CARBOLINES; ALCOHOLISM; MAMMALIAN ALKALOIDS; MORPHINANES; SALSOLINOL; TETRAHYDROISOQUI NOLINES; TETRAHYDROPAPAVEROLINE;

D O I：

10.1055/s-2006-960234

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Beta-carbolines occur in man and rat. The concentration in various tissues is about 100 to 1000 times lower than that of classical neurotransmitters. Administration of beta-carbolines in animals induces overlapping but not identical activity profiles. The molecular modes of action differ. For example, harman (1-methyl-beta-carboline) acts as an endogenous inhibitor of monoamine oxidase [E.C. 1.4.3.4.], subtype A, whereas norharman (beta-carboline) probably acts by stimulation of a specific beta-carboline receptor which is different from the benzodiazepine-GABA receptor complex. There is substantial evidence that tetrahydroisoquinolines occur under physiological conditions as well. Whether tetrahydropapaveroline serves as a precursor of morphinanes in mammals, as has been found in opium poppies, remains to be elucidated.

引用

页码：S85 / S92

页数：8

共 67 条

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