A COMPARATIVE-STUDY OF ENZYMURIA, IN THE RAT, OF THE DRUG-COMBINATIONS AMIKACIN VANCOMYCIN AND AMIKACIN TEICOPLANIN

被引：3

作者：

FAUCONNEAU, B ^{[1
]}

PARIAT, C ^{[1
]}

BOUQUET, S ^{[1
]}

PIRIOU, A ^{[1
]}

INGRAND, P ^{[1
]}

COURTOIS, P ^{[1
]}

机构：

[1] FAC MED & PHARM POITIERS,INST ETUD XENOBIOT,BP 199,34 RUE JARDIN PLANTES,F-86005 POITIERS,FRANCE

来源：

RENAL FAILURE | 1993年 / 15卷 / 04期

关键词：

AMIKACIN; AMINOGLYCOSIDE; ENZYMURIA; NEPHROTOXICITY; TEICOPLANIN; VANCOMYCIN;

D O I：

10.3109/08860229309054961

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this study was to compare nephrotoxicity of the combinations amikacin/vancomycin and amikacin/teicoplanin. Eighteen male Wistar rats were divided into 3 groups of 6 animals each. The first group received 50 mg.kg-1 of amikacin (i.m. route) and 100 mg.kg-1 of vancomycin (i.p. route). The second group received 50 mg.kg-1 of amikacin (i.m. route) and 40 mg.kg-1 of teicoplanin (i.p. route). The third group received an isotonic solution of sodium chloride. The antibiotics were injected for a period of 6 days. Urine samples of animals were taken 24 h before the beginning of the experiment, then every day, throughout the duration of the treatment (6 days), continuing for an additional 3 days following completion of the administration of the drugs. There were no significant modifications in the urinary excretions of alanine aminopeptidase and the creatinine between the 3 groups, but in the group receiving amikacin/teicoplanin, we observed between days 3 and 8 an increase in the excretion of N-acetyl-beta-D-glucosaminidase when compared to the group receiving amikacin/vancomycin (p less-than-or-equal-to 0.05) and to the control group (p less-than-or-equal-to 0.01).

引用

页码：469 / 473

页数：5

共 23 条

[1]

Farber B.F., Moellering R.C., Retrospective study of the toxicity of preparations of vancomycin from 1974 to 1981, Antimicrob Agents Chemother, 23, pp. 138-141, (1983)

[2]

Bouvet A., Cremieux A.C., Contrepois A., Vallois J.M., Lamesch C., Carbon C., Comparison of penicillin and vancomycin, individually and in combination with gentamicin and amikacin, in the treatment of experimental endocarditis induced by nutritionally variant streptococci, Antimicrob Agents Chemother, 28, pp. 607-611, (1985)

[3]

Sato K., Lin T.Y., Weintrub L., Olsen K., McCracken G.H., Bacteriological efficacity of nafcillin and vancomycin alone or combined with rifampicin or amikacin in experimental meningitis due to methicillin-susceptible or -resistant staphylococcus aureus, Jpn J Antibiot, 38, pp. 2155-2162, (1985)

[4]

Wolff M., Regnier B., Garaud J.J., Faurisson F., Concentrations in-tracisternales de vancomycine et amikacine après injections lom-baires, Presse Méd, 12, (1983)

[5]

Humes H.D., Aminoglycoside nephrotoxicity, Kidney Int, 33, pp. 900-911, (1988)

[6]

Palla R., Marchitiello M., Tuoni M., Cirami C., Giovannini L., Ber-Telli A.A.E., Bertelli A., Enzymuria in aminoglycoside-induced kidney damage. Comparative study of gentamicin, amikacin, sisomicin and netilmicin, Int J Clin Pharm Res, 5, pp. 351-355, (1985)

[7]

Tulkens P.M., Nephrotoxicity of aminoglycoside antibiotics, Tox-icol Lett, 46, pp. 107-123, (1989)

[8]

Dean R.P., Wagner D.I., Tolpin M.D., Vancomycin/aminoglycoside nephrotoxicity, J Pediat, 106, pp. 861-862, (1985)

[9]

Wood C.A., Kohlhepp S.J., Kohnen P.W., Houghton D.C., Gilbert D.N., Vancomycin enhancement of experimental tobramycin nephrotoxicity, Antimicrob Agents Chemother, 30, pp. 20-24, (1986)

[10]

Del Bene V.E., John J.F., Twitty J.A., Lewis J.W., Antistaphylococcal activity of teicoplanin, vancomycin and others antimicrobial agents: The significance of methicillin resistance, J Infect Dis, 154, pp. 349-352, (1986)

← 1 2 3 →