A COMPARATIVE-STUDY OF ENZYMURIA, IN THE RAT, OF THE DRUG-COMBINATIONS AMIKACIN VANCOMYCIN AND AMIKACIN TEICOPLANIN

被引：3

作者：

FAUCONNEAU, B ^{[1
]}

PARIAT, C ^{[1
]}

BOUQUET, S ^{[1
]}

PIRIOU, A ^{[1
]}

INGRAND, P ^{[1
]}

COURTOIS, P ^{[1
]}

机构：

[1] FAC MED & PHARM POITIERS,INST ETUD XENOBIOT,BP 199,34 RUE JARDIN PLANTES,F-86005 POITIERS,FRANCE

来源：

RENAL FAILURE | 1993年 / 15卷 / 04期

关键词：

AMIKACIN; AMINOGLYCOSIDE; ENZYMURIA; NEPHROTOXICITY; TEICOPLANIN; VANCOMYCIN;

D O I：

10.3109/08860229309054961

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this study was to compare nephrotoxicity of the combinations amikacin/vancomycin and amikacin/teicoplanin. Eighteen male Wistar rats were divided into 3 groups of 6 animals each. The first group received 50 mg.kg-1 of amikacin (i.m. route) and 100 mg.kg-1 of vancomycin (i.p. route). The second group received 50 mg.kg-1 of amikacin (i.m. route) and 40 mg.kg-1 of teicoplanin (i.p. route). The third group received an isotonic solution of sodium chloride. The antibiotics were injected for a period of 6 days. Urine samples of animals were taken 24 h before the beginning of the experiment, then every day, throughout the duration of the treatment (6 days), continuing for an additional 3 days following completion of the administration of the drugs. There were no significant modifications in the urinary excretions of alanine aminopeptidase and the creatinine between the 3 groups, but in the group receiving amikacin/teicoplanin, we observed between days 3 and 8 an increase in the excretion of N-acetyl-beta-D-glucosaminidase when compared to the group receiving amikacin/vancomycin (p less-than-or-equal-to 0.05) and to the control group (p less-than-or-equal-to 0.01).

引用

页码：469 / 473

页数：5

共 23 条

[11]

Hofmeister R., Bhargava A.S., GUNzel P., Value of enzyme determinations in urine for the diagnosis of nephrotoxicity in rats, Clin Chim Acta, 160, pp. 163-167, (1986)

[12]

Guder W.G., Ross B.D., Enzyme distribution along the nephron, Kidney Int, 26, pp. 101-111, (1984)

[13]

Jung K., Scholz D., An optimized assay of alanine aminopeptid-ase activity urine, Clin Chem, 26, pp. 1251-1254, (1980)

[14]

Maruhn D., Rapid colorimetric assay of beta-galactosidase and N-acetyl-beta-glucosaminidase in human urine, Clin Chim Acta, 73, pp. 453-461, (1976)

[15]

Jaffe M.Z., Über den Niederschlag, welchen Pikrinsaure in nor-malen Harn erzeugt und über eine neue Reaktion des Kreatinins, Z Physiol Chem, 10, pp. 391-400, (1886)

[16]

Aronoff G.R., Sloan R.S., Dinwiddie C.B., Giant M.D., Fineberg N.S., Luft F.C., Effects of vancomycin on renal function in rats, Antimicrob Agents Chemother, 19, pp. 306-308, (1981)

[17]

Cook F.V., Fatrar W.E., Vancomycin revisited, Ann Intern Med, 88, pp. 813-818, (1978)

[18]

Marre R., Schulz E., Graefe H., Sack K., Teicoplanin: Renal tolerance and pharmacokinetics in rats, J Antimicrob Chemother, 20, pp. 697-704, (1987)

[19]

Vandewalle A., Farman N., Morin J.P., Fillastre J.P., Hatt P.Y., Bon-Valet J.P., Gentamicin incorporation along the nephron: Autorad-iographic study on isolated tubules, Kidney Int, 19, pp. 529-539, (1981)

[20]

Pastoriza-Munoz E., Bowman R.L., Kaloyanides G.J., Renal tubular transport of gentamicin in the rat, Kidney Int, 16, pp. 440-450, (1979)

← 1 2 3 →