IMMUNOHISTOCHEMICAL LOCALIZATION OF CALCIUM-BINDING PROTEINS IN THE HUMAN CUTANEOUS SENSORY CORPUSCLES

被引：15

作者：

DELVALLE, ME ^{[1
]}

VAZQUEZ, E ^{[1
]}

REPRESA, J ^{[1
]}

MALINOVSKY, L ^{[1
]}

VEGA, JA ^{[1
]}

机构：

[1] UNIV OVIEDO,FAC MED,DEPT MORFOL & BIOL CELULAR,E-33006 OVIEDO,SPAIN

来源：

NEUROSCIENCE LETTERS | 1994年 / 168卷 / 1-2期

关键词：

CALCIUM-BINDING PROTEIN; CALBINDIN D28K; PARVALBUMIN; S-100; PROTEIN; CUTANEOUS MECHANORECEPTOR; HUMAN;

D O I：

10.1016/0304-3940(94)90461-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The localization of the calcium-binding proteins (CaBP) calbindin-D-28k (CB), parvalbumin (PV) and S-100 protein (S100P) in the human cutaneous sensory corpuscles was studied by immunohistochemical procedure using monoclonal antibodies. Occurrence of CB, PV and S100P immunoreactivity (IR) was observed in the lamellar cells of Meissner's corpuscles. In the pacinian corpuscles, S100P IR was restricted to the inner-core cells whereas CB and PV IR were found labelling the axon, inner core, outer core and capsule. At the light-microscope level of resolution, the presence of IR in the axon of Meissner's corpuscles cannot be ensured. Since calcium ions (Ca2+) seem to participate in the mechanoreceptor electrogenesis, present results suggest that CaBP could be involved in buffering and/or transport of Ca2+ within the specialized cells surrounding the axon tips of sensory corpuscles, thus, maintaining the periaxonal microenvironment.

引用

页码：247 / 250

页数：4

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