BIOACTIVITY OF RECOMBINANT FELINE INTERLEUKIN-2 ON HUMAN AND FELINE LEUKOCYTES

被引:7
作者
COZZI, PJ
PADRID, P
TOMPKINS, MB
ALEGRE, ML
TAKEDA, J
LEFF, AR
机构
[1] UNIV CHICAGO, DEPT MED, PULM & CRIT CARE MED SECT, CHICAGO, IL 60637 USA
[2] N CAROLINA STATE UNIV, COLL VET MED, DEPT MICROBIOL PATHOL & PARASITOL, RALEIGH, NC 27606 USA
[3] UNIV CHICAGO, BEN MAY INST, COMM IMMUNOL, CHICAGO, IL 60637 USA
[4] UNIV CHICAGO, HOWARD HUGHES MED INST, CHICAGO, IL 60513 USA
关键词
FELINE; INTERLEUKIN-2; LYMPHOCYTE; ASTHMA; IMMUNODEFICIENCY VIRUS;
D O I
10.1016/0165-2427(95)05422-3
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Interleukin(IL) -2 is a 16 000 Da protein product of T lymphocytes which is the principle cytokine responsible for clonal expansion of T lymphocytes as a response to antigen exposure, Deficiency of functional IL-2 plays a pivotal role in the pathogenesis of human immunodeficiency syndrome and may be important in the pathogenesis of feline immunodeficiency syndrome as well, Additionally, IL-2 may enhance secretion of interleukin-5 from the TH2 subset of CD4+ T cells, promote peripheral and systemic eosinophilia, and contribute to the eosinophilia which characterizes the inflamed airways of human beings and cats with asthma. We recently reported the sequence of feline IL-2 and the synthesis of recombinant feline IL-2. The purpose of the present study was to evaluate the bioactivity of recombinant feline IL-2 on human and feline leukocytes. We established dose-response relationships between recombinant feline IL-2 and radiolabeled proliferating human and feline leukocytes using thymidine incorporation as a marker of bioactivity. We found that recombinant human IL-2 promotes proliferation of both human and feline leukocytes. However, recombinant feline IL-2 promotes proliferation of feline cells, but not human cells.
引用
收藏
页码:27 / 33
页数:7
相关论文
共 18 条
[1]   PARAMETERS OF PRODUCTION AND PARTIAL CHARACTERIZATION OF FELINE INTERLEUKIN-2 [J].
BAUER, RM ;
OLSEN, RG .
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 1988, 19 (3-4) :173-183
[2]   DEFECTIVE T-CELL RESPONSE TO PHA AND MITOGENIC MONOCLONAL-ANTIBODIES IN MALE-HOMOSEXUALS WITH ACQUIRED IMMUNODEFICIENCY SYNDROME AND ITS INVITRO CORRECTION BY INTERLEUKIN-2 [J].
CIOBANU, N ;
WELTE, K ;
KRUGER, G ;
VENUTA, S ;
GOLD, J ;
FELDMAN, SP ;
WANG, CY ;
KOZINER, B ;
MOORE, MAS ;
SAFAI, B ;
MERTELSMANN, R .
JOURNAL OF CLINICAL IMMUNOLOGY, 1983, 3 (04) :332-340
[3]   SEQUENCE AND FUNCTIONAL-CHARACTERIZATION OF FELINE INTERLEUKIN-2 [J].
COZZI, PJ ;
PADRID, PA ;
TAKEDA, J ;
ALEGRE, ML ;
YUHKI, N ;
LEFF, AR .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 194 (03) :1038-1043
[4]   HUMAN RECOMBINANT INTERLEUKIN-2(125) INDUCED INVITRO PROLIFERATION OF EQUINE, CAPRINE, OVINE, CANINE AND FELINE PERIPHERAL-BLOOD LYMPHOCYTES [J].
FENWICK, BW ;
SCHORE, CE ;
OSBURN, BI .
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 1988, 11 (01) :51-60
[5]  
GOITSUKA R, 1986, JPN J VET SCI, V48, P529
[6]   SUPPRESSION OF LYMPHOCYTE BLASTOGENESIS TO MITOGENS IN CATS EXPERIMENTALLY INFECTED WITH FELINE IMMUNODEFICIENCY VIRUS [J].
LIN, DS ;
BOWMAN, DD ;
JACOBSON, RH ;
BARR, MC ;
FEVEREIRO, M ;
WILLIAMS, JR ;
NORONHA, FMO ;
SCOTT, FW ;
AVERY, RJ .
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 1990, 26 (02) :183-189
[7]   CELLULAR-RESPONSES OF CATS WITH PRIMARY TOXOPLASMOSIS [J].
LIN, DS ;
BOWMAN, DD .
JOURNAL OF PARASITOLOGY, 1991, 77 (02) :272-279
[8]   IMPAIRED PRODUCTION OF LYMPHOKINES AND IMMUNE (GAMMA) INTERFERON IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME [J].
MURRAY, HW ;
RUBIN, BY ;
MASUR, H ;
ROBERTS, RB .
NEW ENGLAND JOURNAL OF MEDICINE, 1984, 310 (14) :883-889
[9]  
PADRID PA, 1994, AM REV RESPIR DIS, V149, pA771
[10]  
PADRID PA, 1995, GENETICS ASTHMA