SYNTHESIS, ANTIMICROBIAL DATA AND CORRELATION-ANALYSIS IN A SET OF 2-ALKYL-5-AMIDOBENZOTRIAZOLES

被引：9

作者：

CALIENDO, G

NOVELLINO, E

SAGLIOCCO, G

SANTAGADA, V

SILIPO, C

VITTORIA, A

机构：

[1] NAPLES UNIV,DIPARTIMENTO CHIM FARMACEUT & TOSSICOL,VIA D MONTESANO 49,I-80131 NAPLES,ITALY

[2] FAC MED & CHIRURG NAPLES,IST IGIENE & MED PREVENT 2,I-80131 NAPLES,ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 27卷 / 02期

关键词：

BENZOTRIAZOLES; LIPOPHILICITY; ANTIMICROBIAL ACTIVITY; QSAR;

D O I：

10.1016/0223-5234(92)90105-A

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A set of 2-alkyl-5-amidobenzotriazoles has been prepared and characterized. Shake-flask partition coefficients (log P) and capacity factors (log k') have been experimentally determined. The in vitro antimicrobial activity against Gram-positive, Gram-negative and Candida albicans have been correlated, through regression analysis, with the corresponding partition coefficients.

引用

页码：161 / 166

页数：6