A CONVERGENT ROUTE TO CALCITRIOL LACTONE VIA REDUCTIVE CLEAVAGE OF AN ENANTIOPURE GLYCIDYL ETHER

被引：20

作者：

CONROW, RE

机构：

[1] Alcon Laboratories, Inc., Fort Worth

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 35期

关键词：

D O I：

10.1016/S0040-4039(00)73879-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reductive cleavage of the ((1-methyl-1-methoxy)ethyl) ether of (S)-2-methylglycidol with lithium 4,4'-di-t-butylbiphenylide, addition of aldehyde 3 to the resulting beta-lithioalkoxide, followed by acidic hydrolysis, yields the advanced (23S,25R)-calcitriol lactone intermediate 4 plus its 23R epimer (approximately 1:1, 69%).

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页码：5553 / 5554

页数：2

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