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SPIRO-PIPERIDINE NONPEPTIDE NEUROKININ-1 RECEPTOR ANTAGONISTS

被引：7
作者：
ARMOUR, DR
WATSON, SP
PEGG, NA
HERON, NM
MIDDLEMISS, D
CHAN, C
CHOLERTON, TJ
HUBBARD, T
VINADER, MV
DAVIES, HG
COCKER, JD
BAYS, DE
WARD, P
机构：
[1] Glaxo-Wellcome Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, Gunnels Wood Road
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 22期
关键词：
D O I：
10.1016/0960-894X(95)00481-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis and activity of a novel spiro-piperidine non-peptide antagonist (2) of the neurokinin-1 (NK1) receptor is described. Despite having essentially the same solution conformation as CP 99,994 (1) at physiological pH, (2) has reduced affinity for the NK1 receptor.
引用
收藏
页码：2671 / 2676
页数：6
相关论文
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