IMPORTANCE OF PARALLEL VECTORS AND HYDROPHOBIC COLLAPSE OF THE ALIGNED AROMATIC RINGS - DISCOVERY OF A POTENT SUBSTANCE-P ANTAGONIST

被引：35

作者：

DESAI, MC ^{[1
]}

VINCENT, LA ^{[1
]}

RIZZI, JP ^{[1
]}

机构：

[1] PFIZER INC,DIV CENT RES,GROTON,CT 06340

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 37卷 / 25期

关键词：

D O I：

10.1021/jm00051a001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

收藏

页码：4263 / 4266

页数：4

相关论文

共 21 条

[1] Confalone P. N., 1988, ORG REACTIONS, V36, P1
[2] DESAI M, UNPUB
[3] CONFORMATIONALLY RESTRICTED ANALOGS OF CP-99,994 - SYNTHESIS OF A SPIROCYCLIC AMINE
DESAI, MC
LEFKOWITZ, SL
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (10) : 2083 - 2086
[4] SYNTHESIS OF (+/-)-CP-99,994 - A HIGHLY POTENT SUBSTANCE-P ANTAGONIST
DESAI, MC
THADEIO, PF
LEFKOWITZ, SL
[J]. TETRAHEDRON LETTERS, 1993, 34 (37) : 5831 - 5834
[5] APPLICATION OF BETA-LACTAMS IN THE SYNTHESIS OF SUBSTANCE-P ANTAGONISTS - PREPARATION OF 2-AZABICYCLO[3.3.1]NONANE RING-SYSTEMS
DESAI, MC
LEFKOWITZ, SL
[J]. TETRAHEDRON LETTERS, 1994, 35 (27) : 4701 - 4704
[6] DISCOVERY OF A POTENT SUBSTANCE-P ANTAGONIST - RECOGNITION OF THE KEY MOLECULAR DETERMINANT
DESAI, MC
LEFKOWITZ, SL
THADEIO, PF
LONGO, KP
SNIDER, RM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (26) : 4911 - 4913
[7] DESAI MC, 1994, EXPERT OPIN THER PAT, V4, P315
[8] DESAI MC, 1994, BIOORG MED CHEM LETT, V37, P1865
[9] STEREOSELECTIVE SYNTHESIS OF (+/-)-INDOLIZIDINES 167B, 205A, AND 207A - ENANTIOSELECTIVE SYNTHESIS OF (-)-INDOLIZIDINE 209B
HOLMES, AB
SMITH, AL
WILLIAMS, SF
HUGHES, LR
LIDERT, Z
SWITHENBANK, C
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (04) : 1393 - 1405
[10] MOLECULAR RECOGNITION IN AQUEOUS-MEDIA - NEW BINDING-STUDIES PROVIDE FURTHER INSIGHTS INTO THE CATION-PI INTERACTION AND RELATED PHENOMENA
KEARNEY, PC
MIZOUE, LS
KUMPF, RA
FORMAN, JE
MCCURDY, A
DOUGHERTY, DA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (22) : 9907 - 9919