APPLICATION OF BETA-LACTAMS IN THE SYNTHESIS OF SUBSTANCE-P ANTAGONISTS - PREPARATION OF 2-AZABICYCLO[3.3.1]NONANE RING-SYSTEMS

被引：11

作者：

DESAI, MC ^{[1
]}

LEFKOWITZ, SL ^{[1
]}

机构：

[1] PFIZER INC, DIV CENT RES, GROTON, CT 06340 USA

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 27期

关键词：

D O I：

10.1016/S0040-4039(00)76945-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Intramolecular ureidomercuration of beta-aminoacids synthesized from appropriate beta-lactams provides an expeditious route to the synthesis of 2-aza-bicyclo[3.3.1]nonane ring systems. Synthesis of the locked-in chair conformer 2 of CP-99,994 is described.

引用

页码：4701 / 4704

页数：4

共 23 条

[1] ALMOND MR, 1988, ORG SYNTH, V66, P132
[2] STEREOCONTROLLED CYCLOFUNCTIONALIZATIONS OF DOUBLE-BONDS THROUGH HETEROCYCLIC INTERMEDIATES
CARDILLO, G
ORENA, M
[J]. TETRAHEDRON, 1990, 46 (10) : 3321 - 3408
[3] CHANG MM, 1970, J BIOL CHEM, V245, P4784
[4] SILICON-ASSISTED SYNTHESIS OF BETA-LACTAMS
COLVIN, EW
MCGARRY, D
NUGENT, MJ
[J]. TETRAHEDRON, 1988, 44 (13) : 4157 - 4172
[5] TETRAHYDROPYRIDONES VIA INTRAMOLECULAR UREIDOMERCURATION
DANISHEFSKY, S
TANIYAMA, E
WEBB, RR
[J]. TETRAHEDRON LETTERS, 1983, 24 (01) : 11 - 14
[6] CONFORMATIONALLY RESTRICTED ANALOGS OF CP-99,994 - SYNTHESIS OF A SPIROCYCLIC AMINE
DESAI, MC
LEFKOWITZ, SL
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (10) : 2083 - 2086
[7] SYNTHESIS OF (+/-)-CP-99,994 - A HIGHLY POTENT SUBSTANCE-P ANTAGONIST
DESAI, MC
THADEIO, PF
LEFKOWITZ, SL
[J]. TETRAHEDRON LETTERS, 1993, 34 (37) : 5831 - 5834
[8] DISCOVERY OF A POTENT SUBSTANCE-P ANTAGONIST - RECOGNITION OF THE KEY MOLECULAR DETERMINANT
DESAI, MC
LEFKOWITZ, SL
THADEIO, PF
LONGO, KP
SNIDER, RM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (26) : 4911 - 4913
[9] DESAI MC, 1994, EXPERT OPIN THER PAT, V4, P315
[10] DESAI MC, 1994, J MED CHEM, V36

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