THEONELLAMIDES A-E, CYTOTOXIC BICYCLIC PEPTIDES, FROM A MARINE SPONGE THEONELLA SP

被引：111

作者：

MATSUNAGA, S ^{[1
]}

FUSETANI, N ^{[1
]}

机构：

[1] UNIV TOKYO,FAC AGR,MARINE BIOCHEM LAB,BUNKYO KU,TOKYO 113,JAPAN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1995年 / 60卷 / 05期

关键词：

D O I：

10.1021/jo00110a020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Five new cytotoxic peptides, related to theonellamide F (1), were isolated from a marine sponge Theonella sp. Theonellamide A (2) and B (3) differ from F (1) in three amino acid residues. Additionally, theonellamide A (2) bears a beta-D-galactose linked to the free imidazole nitrogen; Theonellamide C (4) is debromo 1. Theonellamide D (5) and E (6) are the beta-L-arabinoside and beta-D-galactoside of 1. Structures 2-6 were assigned on the basis of spectral data and chromatographic analyses of degradation products.

引用

页码：1177 / 1181

页数：5

共 16 条

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