GLYCOTHIOHEXIDE-ALPHA, A NOVEL ANTIBIOTIC PRODUCED BY SEBEKIA SP, LL-14E605 .3. STRUCTURAL ELUCIDATION

被引:33
作者
NORTHCOTE, PT
SIEGEL, M
BORDERS, DB
LEE, MD
机构
[1] AMER CYANAMID CO,DIV MED RES,NAT PROD RES SECT,PEARL RIVER,NY 10965
[2] AMER CYANAMID CO,DIV MED RES,ANALYT BIOANALYT RES & DEV SECT,PEARL RIVER,NY 10965
关键词
D O I
10.7164/antibiotics.47.901
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The chemical structure of a novel thiopeptide antibiotic, glycothiohexide alpha (1), isolated from the fermentation broth of a ''Sebekia'' species was determined based on extensive 2D NMR studies, as well as, IR, UV, and mass spectral data. The chemical structure of glycothiohexide alpha is closely related to nosiheptide (3) and antibiotic S-54832A.
引用
收藏
页码:901 / 908
页数:8
相关论文
共 5 条
[1]   MYCOTHIAZOLE, A POLYKETIDE HETEROCYCLE FROM A MARINE SPONGE [J].
CREWS, P ;
KAKOU, Y ;
QUINOA, E .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (13) :4365-4368
[2]  
Keller-Juslen C., 1984, USA patent, Patent No. [US 4,478,831, 4478831]
[3]   H-1 AND C-13 NMR ASSIGNMENTS OF THE THIOPEPTIDE ANTIBIOTIC NOSIHEPTIDE [J].
MOCEK, U ;
CHEN, LC ;
KELLER, PJ ;
HOUCK, DR ;
BEALE, JM ;
FLOSS, HG .
JOURNAL OF ANTIBIOTICS, 1989, 42 (11) :1643-1648
[4]   GLYCOTHIOHEXIDE-ALPHA, A NOVEL ANTIBIOTIC PRODUCED BY SEBEKIA SP, LL-14E605 .2. ISOLATION AND PHYSICAL-CHEMICAL CHARACTERIZATION [J].
NORTHCOTE, PT ;
WILLIAMS, D ;
MANNING, JK ;
BORDERS, DB ;
MAIESE, WM ;
LEE, MD .
JOURNAL OF ANTIBIOTICS, 1994, 47 (08) :894-900
[5]   GLYCOTHIOHEXIDES, NOVEL ANTIBIOTICS PRODUCED BY SEBEKIA SP LL-14E605 .1. TAXONOMY, FERMENTATION AND BIOLOGICAL EVALUATION [J].
STEINBERG, DA ;
BERNAN, VS ;
MONTENEGRO, DA ;
ABBANAT, DR ;
PEARCE, CJ ;
KORSHALLA, JD ;
JACOBUS, NV ;
PETERSEN, PJ ;
MROCZENSKIWILDEY, MJ ;
MAIESE, WM ;
GREENSTEIN, M .
JOURNAL OF ANTIBIOTICS, 1994, 47 (08) :887-893