GLYCOTHIOHEXIDE-ALPHA, A NOVEL ANTIBIOTIC PRODUCED BY SEBEKIA SP, LL-14E605 .2. ISOLATION AND PHYSICAL-CHEMICAL CHARACTERIZATION

被引：20

作者：

NORTHCOTE, PT ^{[1
]}

WILLIAMS, D ^{[1
]}

MANNING, JK ^{[1
]}

BORDERS, DB ^{[1
]}

MAIESE, WM ^{[1
]}

LEE, MD ^{[1
]}

机构：

[1] AMER CYANAMID CO,DIV MED RES,NAT PROD RES SECT,PEARL RIVER,NY 10965

来源：

JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 08期

关键词：

D O I：

10.7164/antibiotics.47.894

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Glycothiohexide alpha was recovered from the fermentation broth of a ''Sebekia'' sp. by mixed solvent extraction, selective precipitation and adsorption chromatography on Diaion HP-20. The amount of glycothiohexide cc present in the crude preparation was enriched by photolysis. Purification of glycothiohexide alpha was accomplished by repetitive countercurrent chromatography.

引用

页码：894 / 900

页数：7

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