RECURRENT MISCARRIAGE

被引:45
作者
KATZ, VL
KULLER, JA
机构
[1] Department of Obstetrics & Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina
关键词
RECURRENT MISCARRIAGE; SPONTANEOUS ABORTION; HABITUAL ABORTION; CHROMOSOMAL ANOMALIES;
D O I
10.1055/s-2007-994603
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The perinatologists are emerging as the physicians who evaluate and treat women with recurrent pregnancy loss. Recurrent miscarriage, previously referred to as habitual abortion, affects almost 1% of couples. The etiologies of recurrent miscarriage are diverse and may be divided into genetic defects, such as chromosomal anomalies; maternal reproductive anatomic disease, both developmental and acquired, such as septate uterus or cervical incompetence; and systemic maternal disease such as antiphospholipid antibody syndrome or maternal diabetes. A cause for recurrent miscarriage can be identified approximately 60% of the time. We emphasize the tremendous psychological impact of recurrent miscarriage. We contrast any proposed treatments with the empiric fact that with no treatment after recurrent losses, couples still have a 60 to 70% chance of delivering a viable infant.
引用
收藏
页码:386 / 397
页数:12
相关论文
共 198 条
[51]  
Poland B.J., Miller J.R., Harris M., Livingston J., Spontaneous abortion: a study of 1961 women and their concept lises, Acta Obstet Gynecol Scand Suppl, 102, pp. 5-32, (1981)
[52]  
Boue J., Bon A., Lazar P., Retrospective and prospective epidemiological studies of 1500 karyotyped spontaneous human abortions, Teratology, 12, pp. 11-26, (1975)
[53]  
Simpson J.L., Genes, chromosomes, and reproductive fail- ure. Fértil Steril, 33, (1980)
[54]  
Johnson M.P., Drugan A., Koppitch F.C., Uhlmann W.R., Ml E., Postmortem chorionic villus sampling is a better method for cytogenetic evaluation of early fetal loss than culture of abonus material, Am J Obstet Gvne-col, 163, (1990)
[55]  
Ohno M., Maeda T., Matsunobu A., A cytogenetic study of spontaneous abortions with direct analysis of chorionic villi, Obstet Gynecol, 77, (1991)
[56]  
Creasy R., The cytogenetics of spontaneous abortion in humans, Beard KW. Sharp F. eds. Early pregnancy loss: mechanisms and treatment. London: SpringerVerlag., pp. 293-301, (1988)
[57]  
Kalousek D.R., Patltology of abortion: chromosomal and genetic correlations, Pathology of reproductive failure, (1991)
[58]  
Simpson J.L., Fetal wastage, Obstetrics: not mal and problem pregnancies, pp. 783-808, (1991)
[59]  
Carr D.H., Chromosome anomalies as a cause of sponta- neous abortion, An J Obslet Gynecol, 94, (1967)
[60]  
Kajii T., Ferrier A., Niikawa N., Et al., Anatomic and chromo- somal anomalies in 639 spontaneous abortuses, Hum Genet, 55, pp. 87-98, (1980)