LOCALIZATION TO CHROMOSOME-10 OF A LOCUS INFLUENCING MORPHINE ANALGESIA IN CROSSES DERIVED FROM C57BL/6 AND DBA/2 STRAINS

被引：83

作者：

BELKNAP, JK

MOGIL, JS

HELMS, ML

RICHARDS, SP

OTOOLE, LA

BERGESON, SE

BUCK, KJ

机构：

[1] OREGON HLTH SCI UNIV, DEPT MED PSYCHOL, PORTLAND, OR 97201 USA

[2] OREGON HLTH SCI UNIV, DEPT BIOCHEM & MOLEC BIOL, PORTLAND, OR 97201 USA

来源：

LIFE SCIENCES | 1995年 / 57卷 / 10期

基金：

美国国家卫生研究院;

关键词：

ANALGESIA; BXD; C57BL/6; DBA/2; OPIOID RECEPTORS; QTL MAPPING;

D O I：

10.1016/0024-3205(95)02040-P

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A quantitative trait locus (QTL) was detected and mapped to proximal chromosome 10 near the markers Mpmv5 and D10Mit51 with a strong influence on morphine-induced analgesia in the BXD recombinant inbred (RI) strains and in an F-2 cross (B6D2F2) between the BXD progenitor strains, C57BL/6 and DBA/2. A LOD score of 3.9 (p<.00002) was seen for analgesia using the hot plate assay. Naloxone Bmax was also associated with this chromosome region in BXD RI mice. The mu opioid receptor gene (Oprm) has recently been mapped to this same chromosome region. The observation that several morphine-related traits and naloxone Bmax appear to be partly determined by this presumed single locus is consistent with the hypothesis that the mu opioid receptor gene, or one of its modulators, is the basis for the QTL.

引用

页码：PL117 / PL124

页数：8

共 29 条

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