DIASTEREOSELECTIVE ADDITION OF ORGANOMETALLIC REAGENTS TO CHIRAL IMINIUM IONS - SYNTHESIS OF (S)-(+)-CRYPTOSTYLINE-I

被引：54

作者：

POLNIASZEK, RP

DILLARD, LW

机构：

[1] Paul M. Gross Chemical Laboratories, Department of Chemistry, Duke University, Durham

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(00)94630-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Iminium ion 2c participates in stereoselective nucleophilic addition reactions with Grignard reagents. Analysis of the products from reaction of 5-hexenylmagnesium bromide with iminium ion 2a suggests that these reactions proceed by a polar (two electron) mechanism. The utility of this chemistry is demonstrated in a stereospecific synthesis of (S)-(+)-cryptostylina I. © 1990.

引用

页码：797 / 800

页数：4

共 18 条

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