OLEFIN OXIDATIVE CLEAVAGE AND DIOXETANE FORMATION USING TRIETHYLSILYL HYDROTRIOXIDE - APPLICATIONS TO PREPARATION OF POTENT ANTIMALARIAL 1,2,4-TRIOXANES

被引：48

作者：

POSNER, GH ^{[1
]}

OH, CH ^{[1
]}

MILHOUS, WK ^{[1
]}

机构：

[1] WALTER REED ARMY MED CTR, DIV EXPTL THERAPEUT, WASHINGTON, DC 20307 USA

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(00)92136-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxidative cleavage of alkenyl esters and ethers using Et3SiOOOH was found to be easier than oxidative cleavage of hydrocarbon alkenes, and Et3SiOOOH was successfully applied to very short syntheses of new, simple, and potent antimalarial trioxanes 6 and 8.

引用

页码：4235 / 4238

页数：4

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