DIFFERENTIAL LOCALIZATION OF A2A ADENOSINE RECEPTOR MESSENGER-RNA WITH D1 AND D2 DOPAMINE-RECEPTOR MESSENGER-RNA IN STRIATAL OUTPUT PATHWAYS FOLLOWING A SELECTIVE LESION OF STRIATONIGRAL NEURONS

被引：67

作者：

POLLACK, AE

HARRISON, MB

WOOTEN, GF

FINK, JS

机构：

[1] MASSACHUSETTS GEN HOSP, MOLEC NEUROBIOL LAB, BOSTON, MA 02114 USA

[2] HARVARD UNIV, SCH MED, DEPT NEUROL, BOSTON, MA 02114 USA

[3] UNIV VIRGINIA, DEPT NEUROL, CHARLOTTESVILLE, VA 22908 USA

来源：

BRAIN RESEARCH | 1993年 / 631卷 / 01期

关键词：

IN SITU HYBRIDIZATION; VOLKENSIN; BASAL GANGLIA; STRIATUM; A2 ADENOSINE RECEPTOR;

D O I：

10.1016/0006-8993(93)91204-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have used the suicide transport agent volkensin to produce selective lesions of striatonigral neurons. By in situ hybridization histochemistry unilateral volkensin injections in the substantia nigra decreased the number of D1 receptor mRNA-expressing neurons in the ipsilateral striatum but did not change the number of D2 receptor and A2a adenosine receptor mRNA-expressing neurons. These findings confirm that striatonigral neurons express D1 receptors and suggest that D2-A2a receptor expressing neurons are predominantly localized to other neuronal populations within the striatum.

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收藏

页码：161 / 166

页数：6

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