EFFICIENT DESULFURIZATION OF 2-THIOPYRIMIDINE NUCLEOSIDES TO THE CORRESPONDING 4-PYRIMIDINONES

被引：14

作者：

KUIMELIS, RG ^{[1
]}

NAMBIAR, KP ^{[1
]}

机构：

[1] UNIV CALIF DAVIS,DEPT CHEM,DAVIS,CA 95616

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(00)79235-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A procedure is described for the preparation of 2'-deoxy-4-pyrimidinone (dH2U) and 2'-deoxy-5-methyl-4-pyrimidinone (dH2T) nucleosides. The key transformation is a nearly quantitative desulfurization of the corresponding 2-thio analogue by a brief treatment with a m-chloroperbenzoic acid/pyridine solution. The phosphoramidites of these nucleosides have also been synthesized.

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页码：3813 / 3816

页数：4

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