STIMULATION OF SYNAPTOSOMAL FREE-RADICAL PRODUCTION BY FATTY-ACIDS - RELATION TO ESTERIFICATION AND TO DEGREE OF UNSATURATION

被引：35

作者：

BONDY, SC ^{[1
]}

MARWAH, S ^{[1
]}

机构：

[1] UNIV CALIF IRVINE, CTR ENVIRONM & OCCUPAT HLTH, DEPT COMMUNITY & ENVIRONM MED, IRVINE, CA 92717 USA

来源：

FEBS LETTERS | 1995年 / 375卷 / 1-2期

关键词：

ETHANOL; FREE RADICAL; FATTY ACIDS;

D O I：

10.1016/0014-5793(95)01173-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of three fatty acids and their respective ethyl esters, to promote generation of reactive oxygen species (ROS), was compared in a preparation of rat brain synaptosomes, Arachidonic but not palmitic or linoleic acids promoted ROS generation, Ethyl esterification of each fatty acid significantly enhanced ROS production and also levels of lipid peroxidation, Pro-oxidant activity was enhanced by fatty acids, proportionally to their degree of unsaturation, Since ethanol consumption is known to lead to esterification of membrane lipids, this transformation may in part account for the ROS-promoting potential of alcohol.

引用

页码：53 / 55

页数：3

共 18 条

[1]

BASS DA, 1983, J IMMUNOL, V130, P1910

[2] FETAL ALCOHOL SYNDROME AND FATTY-ACID ETHYL-ESTERS [J].