SENSITIVITY IMPROVEMENT IN ISOTROPIC MIXING (TOCSY) EXPERIMENTS

A simple modification of the two-dimensional TOCSY experiment which leads to a √2 improvement in sensitivity is described. This improvement is achieved by retaining the magnetization transfer pathways from both of the orthogonal, in-phase magnetization components which are present during the isotropic mixing period. In addition, a simple baseline correction procedure which can greatly improve the quality of NMR spectra is described. © 1990.