SUPPRESSION OF GUINEA-PIG ILEUM INDUCED CONTRACTILITY BY PLASMA-ALBUMIN OF HIBERNATORS

被引:9
作者
BRUCE, DS
AMBLER, DL
HENSCHEL, TM
OELTGEN, PR
NILEKANI, SP
AMSTRUP, SC
机构
[1] VET ADM MED CTR,LEXINGTON,KY 40511
[2] UNIV KENTUCKY,COLL MED,DEPT PATHOL,LEXINGTON,KY 40511
[3] US FISH & WILDLIFE SERV,ALASKA FISH & WILDLIFE RES CTR,ANCHORAGE,AK
关键词
HIBERNATION; WOODCHUCK; GROUND SQUIRREL; BLACK BEAR; POLAR BEAR; GUINEA PIG ILEUM; HIBERNATION INDUCTION TRIGGER;
D O I
10.1016/0091-3057(92)90658-3
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Previous studies suggest that hibernation may be regulated by internal opioids and that the putative "hibernation induction trigger" (HIT) may itself be an opioid. This study examined the effect of plasma albumin (known to bind HIT) on induced contractility of the guinea pig ileum muscle strip. Morphine (400 nM) depressed contractility and 100 nM naloxone restored it. Ten milligrams of lyophilized plasma albumin fractions from hibernating ground squirrels, woodchucks, black bears, and polar bears produced similar inhibition, with partial reversal by naloxone. Five hundredths mg of D-Ala2-D-Leu5-enkephalin (DADLE) also inhibited contractility and naloxone reversed it. Conclusions are that hibernating individuals of these species contain an HIT substance that is opioid in nature and summer animals do not; an endogenous opioid similar to leu-enkephalin may be the HIT compound or give rise to it.
引用
收藏
页码:199 / 203
页数:5
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