PREDOMINANT ACTIVATION OF EXTRATHYMIC T-CELLS DURING MELANOMA DEVELOPMENT OF METALLOTHIONEIN/RET TRANSGENIC MICE

被引:17
作者
IIAI, T
WATANABE, H
IWAMOTO, T
NAKASHIMA, I
ABO, T
机构
[1] NIIGATA UNIV,SCH MED,DEPT IMMUNOL,NIIGATA,NIIGATA 951,JAPAN
[2] NAGOYA UNIV,SCH MED,DEPT IMMUNOL,NAGOYA,AICHI 466,JAPAN
关键词
D O I
10.1006/cimm.1994.1039
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Transgenic mice that carried a metallothionein/ret fusion gene (Tg.MT/ret mice) exhibited severe pigmentation in their skin after birth and developed melanomas at adult ages. To learn how the immune system was modulated during melanoma development in these mice, lymphocytes in various organs were examined. An immunofluorescence cell analysis was focused on the simultaneous characterization of T cells of extrathymic and thymic origins and performed at three time points: 6 weeks of age (before melanoma development). 20 weeks (after melanoma development), and 30 weeks (end stage). The number and proportion of extrathymic T cells with TCR of intermediate intensity (i.e., intermediate TCR cells) were markedly increased in the liver over entire periods of life. These intermediate TCR cells constitutively expressed IL- 2Rβ, contained double-negative CD4 8 cells, and predominated Vβ8+ cells. Such intermediate TCR cells were also abundant among tumor infiltrating lymphocytes. In contrast, an increase in the number and proportion of regular T cells with TCR of bright intensity (i.e., bright TCR cells of thymic origin) was seen at only a limited period in various organs. Rather, at the late phase, thymic atrophy was induced and accompanied with the decrease in the proportion of bright TCR cells in the periphery. These results suggested that extrathymic T cells generated in the liver might play important roles in tumor immunity. © 1994 Academic Press. All rights reserved.
引用
收藏
页码:412 / 427
页数:16
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