LANOMYCIN AND GLUCOLANOMYCIN, ANTIFUNGAL AGENTS PRODUCED BY PYCNIDIOPHORA-DISPERSA .1. DISCOVERY, ISOLATION AND BIOLOGICAL-ACTIVITY

被引：23

作者：

OSULLIVAN, J ^{[1
]}

PHILLIPSON, DW ^{[1
]}

KIRSCH, DR ^{[1
]}

FISHER, SM ^{[1
]}

LAI, MH ^{[1
]}

TREJO, WH ^{[1
]}

机构：

[1] AMER CYANAMID CO,PRINCETON,NJ 08540

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 03期

关键词：

D O I：

10.7164/antibiotics.45.306

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The antifungal agents lanomycin and glucolanomycin were isolated from Pycinidiophora dispersa. The compounds were active against species of Candida and dermatophytes but were inactive against Aspergillus fumigatus and Gram-positive and Gram-negative bacteria. The compounds inhibited the cytochrome P-450 enzyme lanosterol 14-alpha-demethylase, and are believed, therefore, to have a mode of action similar to the azole and bis-triazole class of antifungal agents.

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页码：306 / 312

页数：7

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