LANOMYCIN AND GLUCOLANOMYCIN, ANTIFUNGAL AGENTS PRODUCED BY PYCNIDIOPHORA-DISPERSA .2. STRUCTURE ELUCIDATION

被引：16

作者：

PHILLIPSON, DW ^{[1
]}

OSULLIVAN, J ^{[1
]}

JOHNSON, JH ^{[1
]}

BOLGAR, MS ^{[1
]}

KAHLE, AD ^{[1
]}

机构：

[1] NAT PROD SCI INC,SALT LAKE CITY,UT 84108

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 03期

关键词：

D O I：

10.7164/antibiotics.45.313

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two novel antifungal agents, lanomycin and glucolanomycin, as well as a biologically inactive degradation product, lanomycinol, were isolated from liquid fermentations of Pycnidiophora dispersa. All three compounds share an E,E,E-triene appended to a pyran ring. Lanomycin contains a glycine ester and glucolanomycin possesses a glucose unit attached to the glycine nitrogen. The structures, including absolute stereochemistry, were determined by spectroscopic analysis and partial chemical degradation. Both of the glycine containing compounds show activity against several pathogenic fungi in vitro.

引用

页码：313 / 319

页数：7

共 10 条

[1]

BREITMAIER E, 1987, CARBON 13 NMR SPECTR, P194

[2]

HANAMITSU K, 1981, Patent No. 18592

[3] STRUCTURE ELUCIDATION OF RESTRICTICIN, A NOVEL ANTIFUNGAL AGENT FROM PENICILLIUM-RESTRICTUM [J].