NUCLEOSIDES AND NUCLEOTIDES .115. SYNTHESIS OF 3-ALKYL-3-DEAZAINOSINES VIA PALLADIUM-CATALYZED INTRAMOLECULAR CYCLIZATION - A NEW CONFORMATIONAL LOCK WITH THE ALKYL GROUP AT THE 3-POSITION OF THE 3-DEAZAINOSINE IN ANTICONFORMATION

被引：11

作者：

AOYAGI, M ^{[1
]}

MINAKAWA, N ^{[1
]}

MATSUDA, A ^{[1
]}

机构：

[1] HOKKAIDO UNIV,FAC PHARMACEUT SCI,KITA 12,NISHI 6,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 01期

关键词：

PALLADIUM-CATALYZED CYCLIZATION; ALLYL AMINE; NUCLEOSIDE; CONFORMATION; NOE;

D O I：

10.1016/S0040-4039(00)60068-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of 3-methyl-3-deazainosine (7a) and 3-ethyl-3-deazainosine (7b) can be done by intramolecular cyclization of 5-iodoimidazole-4-(N-allyl and -crotyl)carboxamide ribosides 4a,b with palladium catalysts. The glycosyl conformer population of 7a,b was analyzed by NOE experiments to be fixed in anti-conformation.

引用

页码：103 / 106

页数：4

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