HILAR SOMATOSTATIN NEURONS ARE MORE VULNERABLE TO AN ISCHEMIC INSULT THAN CA1 PYRAMIDAL NEURONS

被引：63

作者：

MATSUYAMA, T ^{[1
]}

TSUCHIYAMA, M ^{[1
]}

NAKAMURA, H ^{[1
]}

MATSUMOTO, M ^{[1
]}

SUGITA, M ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT INTERNAL MED 1,OSAKA,JAPAN

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1993年 / 13卷 / 02期

关键词：

SOMATOSTATIN; DENTATE HILUS; CEREBRAL ISCHEMIA; ISCHEMIC TOLERANCE; GERBIL; IMMUNOCYTOCHEMISTRY;

D O I：

10.1038/jcbfm.1993.28

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of a very short ischemic insult on hilar somatostatin (SS) neurons were investigated in the gerbil hippocampus by means of immunocytochemistry and in situ hybridization histochemistry. A selective and significant loss of 40% of hilar SS neurons took place after 1 day, and a 60% loss after 7 days following 2 min of ischemia, while no SS neurons were lost during recirculation after 1 min of ischemia. Repeated 2-min periods of ischemia, which induced ischemic tolerance by vulnerable CA1 neurons, caused almost complete loss of hilar SS neurons. This study clearly demonstrates that hilar SS neurons are more vulnerable to ischemic insult than CA1 pyramidal neurons. Ischemic tolerance may be induced during the progressive loss of SS neurons in the hilus by changes in their synaptic connections to CA1 pyramidal neurons.

引用

页码：229 / 234

页数：6

共 27 条

[21] EXCITATORY AMINO-ACID RELEASE AND FREE-RADICAL FORMATION MAY COOPERATE IN THE GENESIS OF ISCHEMIA-INDUCED NEURONAL DAMAGE [J].