THE EFFECT OF FREEZING ON CATTLE SKIN PERMEABILITY

被引：8

作者：

YAZDANIAN, M

机构：

[1] Animal Formulation Development, Merck Research Laboratories, West Point

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 103卷 / 01期

关键词：

FREEZING; STORAGE; CATTLE SKIN; URACIL; HYDROCORTISONE; IVERMECTIN; ABAMECTIN;

D O I：

10.1016/0378-5173(94)90208-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of freezing temperature and storage time on the permeation characteristics of cattle skin as measured by in vitro permeation studies of water, uracil, hydrocortisone, abamectin, and ivermectin was investigated. The effect of freezing at -20 and -70 degrees C on the in vitro permeation of all compounds except abamectin was significant at all storage periods from 2 weeks to 6 months. There appear to be no general trends in the changes of permeation characteristics of the compounds studied due to freezing of the cattle skin.

引用

页码：93 / 96

页数：4

共 10 条

[1]

Barry, 1983, DERMATOLOGICAL FORMU

[2]

BRONAUGH RL, 1983, PERCUTANEOUS ABSORPT, V6

[3]

FLYNN GL, 1983, PERCUTANEOUS ABSORPT, V6, P17

[4] PERCUTANEOUS ABSORPTION - RELEVANCE OF INVITRO DATA [J].