EFFECTS OF SKIN STORAGE-CONDITIONS AND CONCENTRATION OF APPLIED DOSE ON [H-3] T-2 TOXIN PENETRATION THROUGH EXCISED HUMAN AND MONKEY SKIN

被引：36

作者：

KEMPPAINEN, BW

RILEY, RT

PACE, JG

HOERR, FJ

机构：

[1] USDA ARS, RICHARD B RUSSELL AGR RES CTR, ATHENS, GA 30613 USA

[2] USA, MED RES INST INFECT DIS, FREDERICK, MD 21701 USA

[3] ALABAMA DEPT AGR & IND, VET DIAGNOST LAB, AUBURN, AL 36831 USA

来源：

FOOD AND CHEMICAL TOXICOLOGY | 1986年 / 24卷 / 03期

关键词：

D O I：

10.1016/0278-6915(86)90232-2

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Penetration of [3H]T-2 toxin through excised human and monkey skin stored at -60.degree. C was faster than through human and monkey skin stored at 4.degree. C, respectively. The permeability of refrigerated human skin was 34% of the permeability of refrigerated monkey skin. Increasing the concentration of [3H]T-2 toxin applied to the refrigerated monkey skin increased the amount of [3H]T-2 toxin penetrating the skin and enhanced the efficiency of penetration. Metabolites of [3H]T-2 toxin were identified in the receptor fluid bathing the dermal side of the excised human and monkey skin.

引用

页码：221 / 227

页数：7

共 33 条

[1]

BARR AJ, 1979, USERS GUIDE SAS

[2]

BECKLAKE MR, 1980, OCCUPATIONAL PULMONA, P189

[3] LEACHING OF HYDROLYTIC ENZYMES FROM HUMAN-SKIN IN CUTANEOUS PERMEATION STUDIES AS DETERMINED WITH METRONIDAZOLE AND 5-FLUOROURACIL PRO-DRUGS [J].