CHANGES IN THE NEONATAL GONADAL HORMONAL ENVIRONMENT PREVENT BEHAVIORAL SPARING AND ALTER CORTICAL MORPHOGENESIS AFTER EARLY FRONTAL-CORTEX LESIONS IN MALE AND FEMALE RATS

被引：51

作者：

KOLB, B ^{[1
]}

STEWART, J ^{[1
]}

机构：

[1] CONCORDIA UNIV, DEPT PSYCHOL, MONTREAL, PQ H3G 1M8, CANADA

来源：

BEHAVIORAL NEUROSCIENCE | 1995年 / 109卷 / 02期

关键词：

D O I：

10.1037/0735-7044.109.2.285

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effects of perinatal exposure to testicular hormones were studied in male and female rats given medial prefrontal lesions (PFC) on Postnatal Day 7. Hormonally intact rats with PFC lesions showed recovery of performance of the Morris water task but no recovery on a forelimb reaching task. Recovery was abolished in both males gonadectomized at birth and in females given testosterone at birth. Male rats with PFC lesions showed an increase in pyramidal cell spine density. This was blocked in gonadectomized animals. In contrast, female rats with PFC lesions showed an increase in dendritic arbor. This was reduced by perinatal testosterone. Interference with the gonadal hormonal environment reduced the brain's ability to compensate for the effects of early cortical lesions.

引用

页码：285 / 294

页数：10

共 32 条

[1]

BEYER C, 1991, J NEUROSCI, V11, P1325

[2]

COLEMAN PD, 1968, J ANAT, V102, P363

[3] COMPARISON OF THE EFFECTS OF NEONATAL AND ADULT MEDIAL PREFRONTAL CORTEX LESIONS ON FOOD HOARDING AND SPATIAL DELAYED ALTERNATION [J].

DEBRABANDER, JM ;

DEBRUIN, JPC ;

VANEDEN, CG .

BEHAVIOURAL BRAIN RESEARCH, 1991, 42 (01) :67-75

[4] ACTIVATION OF MESOCORTICAL DOPAMINERGIC SYSTEM IN THE RAT IN RESPONSE TO NEONATAL MEDIAL PREFRONTAL CORTEX LESIONS - CONCURRENCE WITH FUNCTIONAL SPARING [J].

DEBRABANDER, JM ;

VANEDEN, CG ;

DEBRUIN, JPC ;

FEENSTRA, MGP .

BRAIN RESEARCH, 1992, 581 (01) :1-9

[5] DOPAMINE SYNAPTIC COMPLEX WITH PYRAMIDAL NEURONS IN PRIMATE CEREBRAL-CORTEX [J].

GOLDMANRAKIC, PS ;

LERANTH, C ;

WILLIAMS, SM ;

MONS, N ;

GEFFARD, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (22) :9015-9019

[6]

Juraska JM, 1990, CEREBRAL CORTEX RAT, P483

[7]

KALSBEEK A, 1990, PROG BRAIN RES, V85, P257

[8] EFFECTS OF NEONATAL THERMAL LESIONING OF THE MESOCORTICAL DOPAMINERGIC PROJECTION ON THE DEVELOPMENT OF THE RAT PREFRONTAL CORTEX [J].

KALSBEEK, A ;

BUIJS, RM ;

HOFMAN, MA ;

MATTHIJSSEN, MAH ;

POOL, CW ;

UYLINGS, HBM .

DEVELOPMENTAL BRAIN RESEARCH, 1987, 32 (01) :123-132

[9] SPARING OF FUNCTION AFTER NEONATAL FRONTAL LESIONS CORRELATES WITH INCREASED CORTICAL DENDRITIC BRANCHING - A POSSIBLE MECHANISM FOR THE KENNARD EFFECT [J].

KOLB, B ;

GIBB, R .

BEHAVIOURAL BRAIN RESEARCH, 1991, 43 (01) :51-56

[10] RECOVERY FROM EARLY CORTICAL DAMAGE IN RATS .1. DIFFERENTIAL BEHAVIORAL AND ANATOMICAL EFFECTS OF FRONTAL LESIONS AT DIFFERENT AGES OF NEURAL MATURATION [J].

KOLB, B .

BEHAVIOURAL BRAIN RESEARCH, 1987, 25 (03) :205-220

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