CHANGES IN THE NEONATAL GONADAL HORMONAL ENVIRONMENT PREVENT BEHAVIORAL SPARING AND ALTER CORTICAL MORPHOGENESIS AFTER EARLY FRONTAL-CORTEX LESIONS IN MALE AND FEMALE RATS

被引：51

作者：

KOLB, B ^{[1
]}

STEWART, J ^{[1
]}

机构：

[1] CONCORDIA UNIV, DEPT PSYCHOL, MONTREAL, PQ H3G 1M8, CANADA

来源：

BEHAVIORAL NEUROSCIENCE | 1995年 / 109卷 / 02期

关键词：

D O I：

10.1037/0735-7044.109.2.285

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effects of perinatal exposure to testicular hormones were studied in male and female rats given medial prefrontal lesions (PFC) on Postnatal Day 7. Hormonally intact rats with PFC lesions showed recovery of performance of the Morris water task but no recovery on a forelimb reaching task. Recovery was abolished in both males gonadectomized at birth and in females given testosterone at birth. Male rats with PFC lesions showed an increase in pyramidal cell spine density. This was blocked in gonadectomized animals. In contrast, female rats with PFC lesions showed an increase in dendritic arbor. This was reduced by perinatal testosterone. Interference with the gonadal hormonal environment reduced the brain's ability to compensate for the effects of early cortical lesions.

引用

页码：285 / 294

页数：10

共 32 条

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