SUPPRESSION OF PIPERIDINE-MEDIATED SIDE PRODUCT FORMATION FOR ASP(OBU(T))-CONTAINING PEPTIDES BY THE USE OF N-(2-HYDROXY-4-METHOXYBENZYL) (HMB) BACKBONE AMIDE PROTECTION

被引：66

作者：

QUIBELL, M

OWEN, D

PACKMAN, LC

JOHNSON, T

机构：

[1] MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

[2] UNIV CAMBRIDGE,DEPT BIOCHEM,CAMBRIDGE CB2 1QW,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 20期

关键词：

D O I：

10.1039/c39940002343

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Piperidine-mediated aspartimide and subsequent piperidide formation, during Fmoc-based synthesis of sensitive aspartyl (beta-tert-butyl ester, OBu(t))-containing peptides, is completely suppressed by the use of Hmb protection of the aspartyl amide bond.

引用

页码：2343 / 2344

页数：2

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