CARDIAC CONTENT OF BRAIN NATRIURETIC PEPTIDE IN DOCA-SALT HYPERTENSIVE RATS

被引:13
作者
YOKOTA, N
ABURAYA, M
YAMAMOTO, Y
KATO, J
KITAMURA, K
KIDA, O
ETO, T
MINAMINO, N
KANGAWA, K
MATSUO, H
TANAKA, K
机构
[1] MIYAZAKI MED COLL,DEPT BIOCHEM,MIYAZAKI 88916,JAPAN
[2] NATL CARDIOVASC CTR,SUITA,OSAKA 565,JAPAN
关键词
D O I
10.1016/0024-3205(91)90494-V
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The cardiac content of immunoreactive rat brain natriuretic peptide (ir-rBNP) in deoxycorticosterone acetate (DOCA) -salt hypertensive rats was measured by radioimmunoassay (RIA). The atrial content of ir-rBNP was significantly lower in the DOCA-salt group than in the control group (p < 0.01). However, the ventricular content of ir-rBNP was markedly increased in the DOCA-salt group as compared to the other groups. Ir-rBNP levels in the atria was negatively correlated with blood pressure (r = -0.49, p < 0.01), while that in the ventricle was positively correlated with blood pressure (r = 0.79, p < 0.001). A significant correlation was observed between tissue levels of ir-rBNP and ir-rat atrial natriuretic peptide (rANP) both in atrium and ventricle (atrium, r = 0.63, p < 0.001 ; ventricle, r = 0.95, p < 0.001). These results raise the possibility that rBNP as well as rANP functions as a cardiac hormone, the production of which probably changes in response to increased of body fluid and blood pressure.
引用
收藏
页码:397 / 402
页数:6
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