IS THERE A ROLE FOR POSITIVE INOTROPIC AGENTS IN CONGESTIVE-HEART-FAILURE - FOCUS ON MORTALITY

被引:7
作者
AMIDON, TM [1 ]
PARMLEY, WW [1 ]
机构
[1] UNIV CALIF SAN FRANCISCO, DEPT MED, SAN FRANCISCO, CA 94143 USA
关键词
CONGESTIVE HEART FAILURE; INOTROPIC THERAPY; SURVIVAL STUDIES;
D O I
10.1002/clc.4960171203
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Congestive heart failure (CHF) is a common clinical syndrome that may result from a variety of etiologies. Impaired contractility can lead to pump failure and a number of hemodynamic and neurohormonal alterations. Vasodilator therapy improves symptoms and survival in patients with CHF due to systolic dysfunction. Inotropic therapy, on the other hand, has not been shown to improve survival and may even worsen survival. This article reviews the mechanism of action and clinical trials of inotropic therapy in patients with CHF.
引用
收藏
页码:641 / 647
页数:7
相关论文
共 55 条
[11]   NEW POSITIVE INOTROPIC AGENTS IN THE TREATMENT OF CONGESTIVE-HEART-FAILURE - MECHANISMS OF ACTION AND RECENT CLINICAL DEVELOPMENTS .2. [J].
COLUCCI, WS ;
WRIGHT, RF ;
BRAUNWALD, E .
NEW ENGLAND JOURNAL OF MEDICINE, 1986, 314 (06) :349-358
[12]   NEW POSITIVE INOTROPIC AGENTS IN THE TREATMENT OF CONGESTIVE-HEART-FAILURE - MECHANISMS OF ACTION AND RECENT CLINICAL DEVELOPMENTS .1. [J].
COLUCCI, WS ;
WRIGHT, RF ;
BRAUNWALD, E .
NEW ENGLAND JOURNAL OF MEDICINE, 1986, 314 (05) :290-299
[13]   FLOSEQUINAN - A VASODILATOR WITH POSITIVE INOTROPIC ACTIVITY [J].
CORIN, WJ ;
MONRAD, ES ;
STROM, JA ;
GIUSTINO, S ;
SONNENBLICK, ES ;
LEJEMTEL, T .
AMERICAN HEART JOURNAL, 1991, 121 (02) :537-540
[14]   LONG-TERM OUTCOME OF ENOXIMONE THERAPY IN PATIENTS WITH REFRACTORY HEART-FAILURE [J].
DEC, GW ;
FIFER, MA ;
HERRMANN, HC ;
COCCASPOFFORD, D ;
SEMIGRAN, MJ .
AMERICAN HEART JOURNAL, 1993, 125 (02) :423-429
[15]   A COMPARISON OF ORAL MILRINONE, DIGOXIN, AND THEIR COMBINATION IN THE TREATMENT OF PATIENTS WITH CHRONIC HEART-FAILURE [J].
DIBIANCO, R ;
SHABETAI, R ;
KOSTUK, W ;
MORAN, J ;
SCHLANT, RC ;
WRIGHT, R .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (11) :677-683
[16]  
DIES F, 1986, CIRCULATION, V74, P38
[17]   THE PARADOX OF BETA-ADRENERGIC-BLOCKADE FOR THE MANAGEMENT OF CONGESTIVE-HEART-FAILURE [J].
EICHHORN, EJ .
AMERICAN JOURNAL OF MEDICINE, 1992, 92 (05) :527-538
[18]   USEFULNESS OF OPC-8212, A QUINOLINONE DERIVATIVE, FOR CHRONIC CONGESTIVE-HEART-FAILURE IN PATIENTS WITH ISCHEMIC-HEART-DISEASE OR IDIOPATHIC DILATED CARDIOMYOPATHY [J].
FELDMAN, AM ;
BAUGHMAN, KL ;
LEE, WK ;
GOTTLIEB, SH ;
WEISS, JL ;
BECKER, LC ;
STROBECK, JE .
AMERICAN JOURNAL OF CARDIOLOGY, 1991, 68 (11) :1203-1210
[19]   EFFECTS OF VESNARINONE ON MORBIDITY AND MORTALITY IN PATIENTS WITH HEART-FAILURE [J].
FELDMAN, AM ;
BRISTOW, MR ;
PARMLEY, WW ;
CARSON, PE ;
PEPINE, CJ ;
GILBERT, EM ;
STROBECK, JE ;
HENDRIX, GH ;
POWERS, ER ;
BAIN, RP ;
WHITE, BG .
NEW ENGLAND JOURNAL OF MEDICINE, 1993, 329 (03) :149-155
[20]   ADDITIVE EFFECTS OF DOBUTAMINE AND AMRINONE ON MYOCARDIAL-CONTRACTILITY AND VENTRICULAR PERFORMANCE IN PATIENTS WITH SEVERE HEART-FAILURE [J].
GAGE, J ;
RUTMAN, H ;
LUCIDO, D ;
LEJEMTEL, TH .
CIRCULATION, 1986, 74 (02) :367-373