DEFICIENCY OF KALLIKREIN-LIKE ENZYME-ACTIVITIES IN CEREBRAL TISSUE OF PATIENTS WITH ALZHEIMERS-DISEASE

被引：98

作者：

AOYAGI, T ^{[1
]}

WADA, T ^{[1
]}

NAGAI, M ^{[1
]}

KOJIMA, F ^{[1
]}

HARADA, S ^{[1
]}

TAKEUCHI, T ^{[1
]}

TAKAHASHI, H ^{[1
]}

HIROKAWA, K ^{[1
]}

TSUMITA, T ^{[1
]}

机构：

[1] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL,ITABASHI KU,TOKYO 173,JAPAN

来源：

EXPERIENTIA | 1990年 / 46卷 / 01期

关键词：

Alzheimer's disease; brain; kallikrein; prolyl endopeptidase; proteases;

D O I：

10.1007/BF01955428

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We examined the changes in the intracerebral activities, at the time of postmortem autopsy, in patients with Alzheimer's disease. When compared with the control group, the activity of kallikrein-like enzyme was significantly decreased, while prolyl endopeptidase activity increased, in the patients group. Aprotinin inhibited 50% of the activity of the former enzyme at 2×10-7M. Taken together with the results of a multivariate study, the above findings may indicate that intracerebral kallikrein deficiency plays an important role in the pathogenesis of Alzheimer's disease. © 1990 Birkhäuser Verlag.

引用

页码：94 / 97

页数：4

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