GENETIC-LINKAGE IS EXCLUDED FOR THE D2-DOPAMINE RECEPTOR LAMBDA-HD2G1 AND FLANKING LOCI ON CHROMOSOME 11Q22-Q23 IN TOURETTE SYNDROME

被引：36

作者：

DEVOR, EJ

GRANDY, DK

CIVELLI, O

LITT, M

BURGESS, AK

ISENBERG, KE

VANDEWETERING, BJM

OOSTRA, B

机构：

[1] OREGON HLTH SCI UNIV,VOLLUM INST ADV BIOMED RES,PORTLAND,OR 97201

[2] OREGON HLTH SCI UNIV,DEPT MED GENET & BIOCHEM,PORTLAND,OR 97201

[3] ERASMUS UNIV,DEPT CLIN GENET,3000 DR ROTTERDAM,NETHERLANDS

来源：

HUMAN HEREDITY | 1990年 / 40卷 / 02期

关键词：

Chromosome; 11q; Linkage; Tourette syndrome;

D O I：

10.1159/000153914

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A genetic linkage study of fifteen families (n = 166) ascertained through probands diagnosed for Tourette syndrome was carried out for the D2dopamine receptor and flanking loci on chromosome 11q22-q23. Tight linkage was excluded for all probes and regions of exclusion up to ±20% recombination were obtained. Overlapping regions of exclusion based upon primary map data permit exclusion of the entire region of the DRD2 locus in Tourette syndrome. © 1990 S. Karger AG, Basel.

引用

页码：105 / 108

页数：4

共 17 条

[11] REPORT OF THE COMMITTEE ON THE GENETIC CONSTITUTION OF CHROMOSOME-11
JUNIEN, C
MCBRIDE, OW
[J]. CYTOGENETICS AND CELL GENETICS, 1989, 51 (1-4): : 226 - 258
[12] ANALYSIS OF HUMAN Y-CHROMOSOME-SPECIFIC REITERATED DNA IN CHROMOSOME VARIANTS
KUNKEL, LM
SMITH, KD
BOYER, SH
BORGAONKAR, DS
WACHTEL, SS
MILLER, OJ
BREG, WR
JONES, HW
RARY, JM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (03) : 1245 - 1249
[13] OTT J, 1985, ANAL HUMAN GENETIC L
[14] THE INHERITANCE OF GILLES-DELATOURETTES SYNDROME AND ASSOCIATED BEHAVIORS - EVIDENCE FOR AUTOSOMAL DOMINANT TRANSMISSION
PAULS, DL
LECKMAN, JF
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (16) : 993 - 997
[15] SHAPIRO A, 1988, G DELATOURETTE SYNDR
[16] DETECTION OF SPECIFIC SEQUENCES AMONG DNA FRAGMENTS SEPARATED BY GEL-ELECTROPHORESIS
SOUTHERN, EM
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1975, 98 (03) : 503 - +
[17] LINKAGE ANALYSIS WITH COHORT EFFECTS - AN APPLICATION TO X-LINKAGE
VANEERDEWEGH, P
[J]. GENETIC EPIDEMIOLOGY, 1989, 6 (01) : 271 - 276

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