MINI-MOUSE - DISRUPTION OF THE PYGMY LOCUS IN A TRANSGENIC INSERTIONAL MUTANT

被引：76

作者：

XIANG, X

BENSON, KF

CHADA, K

机构：

[1] Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway

来源：

SCIENCE | 1990年 / 247卷 / 4945期

关键词：

D O I：

10.1126/science.2305264

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A founder transgenic mouse harbored two different integration patterns ofa transgene at the same locus, each of which gave rise to a similar autosomal recessive mutation. Mice of the mutant phenotype were of small stature but had normal levels of growth hormone. The disrupted locus was cloned, and a genetic and molecular analysis showed that the insertional mutants were alielic to a spontaneous mutant, pygmy. The mice should be a useful model for the growth hormone-resistant human dwarf syndromes and could lead to a greater understanding of the pathways involved in growth and development.

引用

页码：967 / 969

页数：3