HEAT INACTIVATION OF LEUCINE-(C-14) INCORPORATION INTO HEART SLICES - POTENTIATION BY ETHANOL

被引：3

作者：

GAILIS, L ^{[1
]}

机构：

[1] LAVAL UNIV,DEPT MED,QUEBEC G1V 4G5,QUEBEC,CANADA

来源：

GENERAL PHARMACOLOGY | 1979年 / 10卷 / 01期

关键词：

D O I：

10.1016/0306-3623(79)90030-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. 1. Leucine[14C] incorporation into mouse heart slices was measured at 34-43°C. 2. 2. Ethanol had little effect under 37°. Above 40°C, it markedly potentiated the inactivating effect of elevated temperature. 3. 3. Ethanol (200 mM) increased the activation energy of the heat inactivation reaction by 47%, and increased the Q10 from 180 to 2000. 4. 4. A significant effect was seen with 40 mM ethanol. 5. 5. Dimethyl sulfoxide and acetone produced similar effects. 6. 6. Ethanol also potentiated the effect of 2,4-dinitrophenol, which increases endogenous heat production. 7. 7. The results suggest that ethanol decreases the thermal stability of tissues, at concentrations and temperatures that may occasionally be encountered in vivo. © 1979.

引用

页码：57 / 61

页数：5

共 25 条

[1] The equilibrium between active native trypsin and inactive denatured trypsin [J].